First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation
نویسندگان
چکیده
ABSTRACT A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C-H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selective transformation can be performed with different amines and arylboronate esters. Additionally, the directing group can be cleaved, taking advantage of an unprecedented detrifluoromethylation reaction. GRAPHICAL ABSTRACT
منابع مشابه
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عنوان ژورنال:
دوره 144 شماره
صفحات -
تاریخ انتشار 2013